sometimes it doesn't seem they trying though.
Why? If you can off label old stuff, or slightly alter it... and than guilt trip the crazies with "you should feel grateful for these meds?" (as many doctors do... some even have the guts to compare it to cancer treatmet).

My reasons for skepticism in drugs as cure for mental problems... it's that I think there is no way for them to "work" in the way we would like them to. By the nature of these problems that are so extremelly complex. I am skeptic that science can really help here... at least in the way they do it now.