I recently went through this big time. However, it was very knew to me as angry, irrational, irritable is not my behavior. This went on for weeks, I researched and asked and talked no one knew the answer. I'm not sure if it was from mania, mixed state, or the meds. My meds are fairly new , been on it about 6 months, but they said it was abnormal to get that reaction from the med. I went off it recently and i'm no longer this raging lunatic.