Just saw my pdoc today, and what a difference a week makes! Last week I was in the depths of a very bad depression, since then the meds have kicked in and I feel SO MUCH better. In fact, I think I'm a little hypomanic. The combo of depakote with pristiq seems to be working well for me. The pdoc added some more depakote to hopefully prevent me from becoming more manic, but feeling better is such a relief!