I'm on Saphris, and there are things i don't like about it, but it doesn't cause the sense of doom you are describing. Are you sure you are not getting depressed? Because anxiety can be part of depression. Your description doesn't sound like something Saphris would cause, but then you never know, everyone is different.

I have complicated feelings towards Saphris. It took me out of severe depression, and keeps me pretty stable. But it leaves me a little flat, and it stops hypomania, which i really miss. Plus i just don't like the idea of being on an AP because i am not psychotic. I know it is a mood stabilizer too, but it just seems pretty heavy to me, because i think i'm be ok just on lamictal, but my pdoc disagrees. So i struggle with taking it. But it does do what it's supposed to do.