I've been on 400 mg of Seroquel forever. I used to be on lithium but my kidneys quit filtering it out. When the lithium pooped my kidneys out and I kept getting toxic she switched the lithium for Abilify. The Seroquel is supposed to stabilize my mood and work against mania, and 6 mg of Abilify is working well on the depression. I was having a lot of anxiety so she added 1 mg of Risperidone, and it was like magic - I was doing so well, but she wanted to wait 6 months before removing the risperidone again.