It's definitely worth trying other drugs. I started out on concerta but I have such a fast metabolism that even the XR capsule was in and out of my system in about 4-5 hours. I also crashed really badly (headaches, grumpiness, nausea) and I had a super high heart rate. I ended up switching to Strattera. I didn't have any of the side effects but it was less effective for me, even on the highest recommended dose. My advice is to try different meds and then see. If it comes down to it, you might have to weigh the side effects versus the benefit of the medication. But there are tons of meds out there- don't give up until you've tried them all or the one that works best for you.