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It sounds like your sister needs professional help. You can't make her get help. Given your current condition I would focus on taking care of yourself and your kids.
I know it sounds a bit heartless but if my brother was acting the way you describe, I would worry a LOT about him but wouldn't give him any help or assistance until he turned his life around.
I'm sorry you are in such a difficult situation.
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“If we could change ourselves, the tendencies in the world would also change. As a man changes his own nature, so does the attitude of the world change towards him. ... We need not wait to see what others do.” Gandhi
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