Since I'm not a psychiatrist, maybe I shouldn't say this, but here goes....
To the people who have been on several different antidepressants, and who have had them suddenly "stop working", have you ever been tested for bipolar disorder?
I'm not saying you are. I'm just saying for a lot of doctors that's a huge red flag that something other than depression may be going on.

Remember, not all mania in bipolar is rainbows and butterflies. For a lot of people mania equals anxiety and irritability. Just something to think about as you search for answers.