I definitely noticed a difference when I first started taking Lamictal (even on the very low dose) and it definitely wasn't placebo. My sex drive was ramped up and I felt more loving and caring towards my family. My irritability vanished over night and that was the big thing for me. I used to throw things at my husband and break things, it got that bad. But that was 3 years ago. Now I'm on 300mg and the only thing it has done for me is remove my irritability.