I've been on Latuda for a while now and when I first started taking it, it made me exhausted to no end. that lasted about a month or so. now that my body is used to taking it I don't get as tired anymore. I now take Latuda with Lamictal and Lithium, and seems to be a working combination. With the effects of the medication and the hours that you work, that would be hard combination for me to manage.