Yes, Lamictal works great for me. Keeps my irritability subdued. Marijuana also worked wonders, but was really not practical in any way, especially since the effects wear off so quickly. I was using marijuana for 6 months to keep my irritability away, but once I got up to 200 mg of lamictal, I was able to quit the weed immediately with no problems. Lamictal is my wonder-drug. Doesn't work for everyone though.