Hi, so sorry to hear! I've personally battled bipolar depression for 21 years now and there's only a few things that help me out of the dark, torment and agony of horrific depression...med changes every 2-3 months which include proper dosage, and only the SNRIs don't poop out on me. Lithium helps augment the anti-depressants, Latuda is great for bipolar depression, Abilify at 2.5mg-5mg. Sometimes admitting myself to a top psych ward in the country, I love UNI in Utah. Sleeping or napping sometimes relieves the hell of hells, praying and pleading for help and strength to not commit psychological suicide or suicide! Somehow not loosing hope, if I become hopeless I'm in trouble of giving up! Changing my environment! And sunlight or a happy light! And listening to guided imagery by Bellaruth Naparstek. So sorry, it's so painful and total misery at times oh and also that better meds and techniques will come out! Best of luck and hope that helps a bit!!!