I have always taken Eve Primrose no matter what SSRI or other anti-depressant I have been on with no effect to the medication but has helped with PMS bloating and cramps. I know some have to increase their SSRI's during their periods to combat the increase in symptoms of depression and anxiety. I have had to do this as well; I start to slightly increase it 4-5 days before my period and taper it back down, 2-3 days afterward. Talk to your doctor about this and let them know what is going on; they can help.

There are other things that are contraindicated with evening primrose and here is some other information about it:
http://www.nlm.nih.gov/medlineplus/d...ural/1006.html

Wishing you well meanwhile. I hope you find answers and some help soon.