I have been told I have treatment resistant depression. I've tried more drugs and drug combos than I care to remember (30 different drugs, nor counting the various combos they tried them in). It is very frustrating hearing providers trying to convince me that *this* time meds will work. I agree that provides would likely think differently if they had to live with the futility of constantly putting in effort with little to no returns.
I've found the best treatment for myself in times of major depressive episodes (always accompanied by increase in my ptsd symptoms) is intensive and wrap - around services that allow for safe processing of whatever comes up.