OMG! I was on effexsor for over 6 years 300 mg a day. When I decided to come off for a specific reason I had only 2 weeks to come off. So, I tapered off for 2 weeks, as best I could. Lets just say that I will never in my entire life EVER take effexsor again!!!! MY BRAIN WAS VIBRATING AGAINST MY SKULL!! And you know, once i got through it, i felt the same as I did when I was on it, so It wasn't working anyway!!!