Unfortunately it sounds like you've done all that you can do. I would sit down with her and explain everything to her. Urge her to seek out more care in therapy and with medications. Let her know that you'll be starting a new job and won't be able to be there for her all the time. There is NOTHING wrong in anything you've done so far. As far as I can tell, you've been a great friend to her. However, she needs to put her own fears aside and seek further help for her depression without always turning to you. It isn't fair to you. You have set understandable boundaries, and you should be proud of that. You cannot fix her. And, its not fair for her to expect you to always be there for her, even when you aren't in a good place yourself. If you speak to her and urge her to get further help and she still refuses, you may have to distance yourself from her as this doesn't sound like it would be an equal sort of friendship. Yes, friendship is a give and take sort of thing, but it isn't fair for one friend to simply refuse to seek out help and let it all fall into the lap of the other friend. I know you care deeply about this person, but if she refuses to take care of her own needs, then there's not much else that you can do.