It just sounded a lot like me about 10 years ago when my husband left. If I wasn't happy, he wasn't going to be happy. Of course I didn't know this at the time but it makes sense now. I felt unfullfilled, wasn't obtaining my dream (whatever that may be). It just sounds so familiar. And no, I can't talk to her as I am friends with her husband only at work. He is a major caregiver which was a perfect fit but I think after 25 years and the fear of retiring soon with the house not paid off, credit cards is making him rethink everything.
I'm going to suggest they both go to counseling but I think they'd rather cry about it. (that sounds like me also)