I just turned 38, and my PMDD didn't develop until I was 35. Some months it is fine. Other months it is horrible. I do take Zoloft and Buspar regularly. This month was horrible...lots of crying, constant anxiety, significant depression. My periods are still pretty regular, but I am thinking of seeing my doctor if I have another period like this. PMDD just plain stinks. Hugs to you, and make sure you are putting self-care first!