After being on every medication out there...pdoc just started me on latuda as well. Said it just got fda approval for treatment of bipolar depression. I have started out on 20mg for first week, now up to 40mg. He said he has seen suprisingly good results so far woth other patients. The only med i havent tried is seroquel, and i dont want to. I hope this helps us. 3-4 weeks for some minor results. Good luck.