Hi SayHello

Assuming that you have no underlying physical health issues and that you eat in a healthy way it is very unlikely that you are deficient in amino acids like tryptophan and methionine (which is used to make SAM-e).

Similarly it is unlikely that you are deficient in Vitamin B6 (pyridoxal-5-phosphate) - good sources of it include meat, whole grains, vegetables and nuts.

I suggest that you get your doctor to refer you to a registered dietitian - they are evidence-based health professionals who specialize in providing their clients with advice about healthy eating.

In my opinion this is a better approach than using dietary "pill supplements" - unless they are clinically indicated they are likely to be a waste of money.

All the best.