Medication is only part of the answer. You may try others as there are many others and combo's available but if you are getting decent results from what you are taking you may not want to mess with it. Lack of drive and motivation is a very common symptom of depression and may be fixed by meds but low self esteem maybe won't be. It also takes therapy, a lot of self help, meditation, taking risks socially, a good support network. A lot of things to try to slowly build upon.

A lot depends on the core causes of things too. For example if there was trauma, abuse, neglect, etc in childhood one treatment approach may be adopted. If it is very genetic and biological another approach might be adopted.