>The most significant info for me are what are peoples real life experiences with them. "What has worked for you."

Agreed. And I've seen long-term that ADs have seemingly destroyed people I know and short-term caused changes in me that were extremely disturbing.

We need science, because anecdotal evidence is a small part of the picture and lacking in rigour. Yet, we have to make choices in our lives, whether we have excellent info or not. Usually, we have very incomplete info and we have to take action. Hunches are important. That's my last word in this conversation. Going to bow out now.