Yes, I had a nervous breakdown from what I thought was PTSD. I cried for about 5 months and checked myself into the psych ward. The horrible part was I asked my stupid pdoc whom I hate about my hormone levels and he blew me off. As soon as I left I had 2 blood tests and was positive for perimenopause. Just knowing what the problem was, and that I wasn't going insane was somewhat of a relief. The estrogen helps more with night sweats & hot flashes. I think my regular psych meds help more with the mood swings. Sometimes I get irritated or cry but it passes. The biggest problem is lethargy. I used to exercise everyday and it gave me a lot of energy plus I was losing some of the weight I packed on from Seroquel. I know menopause usually slows the metabolism and adds weight so I hope this will pass.