I didn't know mushrooms were dangerous in mild quantities. They made my friends and I laugh and laugh and laugh for hours. I've only tried them once. I have had transient psychotic symptoms/hallucinations, but I tried these things way before I had any noticable mental health issues. I've heard psychedelics might trigger MI, but I don't know if that true.

Ketamine treatment for depression is probably carefully monitored.

Ketamine May Benefit Those With Treatment-Resistant Depression | Psych Central News

Ketamine Nasal Spray Can Offer Quick Depression Relief | Psych Central News