"Another surprising finding is that when put under stress, the knockout mice behaved in the same way most of the normal mice did. And some of the knockout mice responded therapeutically to antidepressant medications in a similar manner to the normal mice."
^ from above article.

Why would the knockout mice respond therapeutically to anti depressants?

http://www.ncbi.nlm.nih.gov/m/pubmed/23089640/

I don't think there is much doubt that mono amines and their transporter receptors or lack of receptors play a role somehow in mental illness. They can't measure their levels in a living human brain. Some recent evidence suggests it could be a lack of certain transporter receptors. They can't say much about the mechanisms of action of AD's in a living human brain. Just by animal models.

Article on knock out mice and 5HT receptors and use of those mice.

http://www.neuropharmacologie.u-psud.fr/Alain_Gardier_files/19179848.pdf

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