YES! My p-doc referred to it as a "negative mania." But he also called it a mixed state. I have never, ever, ever, felt such a hellish feeling in my life. Something like anxiety...dread...agitation...terror....NO PLACE I could go gave any comfort. I'm terrified of it happening again. Btw, a high dose of Zoloft worsened the dysphoric mania...it took me a couple of months to realize I needed to drop my Zoloft dose way, way down.