I've tried Brintellix and Fetzima. Brintellix is supposed to be the most potent and effective SSRI since it targets 7 of the 5-htp receptors, however it didn't work for me. Fetzima, is an SNRI, which typically work much better than SSRIs generally for depression...but Fetzima made me too agitated. According to a study at John Hopkin's, Cymbalta's actually supposed to be the best AD, but everyone is different. Personally, I love Nefazodone, and Cymbalta! Good luck! Btw, they're finding that the SNRIs don't poop out as much or even at all.