I became manic and psychotic on Wellbutrin. Horrible reaction---I was threatening to kill people, screaming and shouting at the top of my lungs. I scared people. Had no idea at the time that I was bipolar. Found out right after this. At the time my pdoc figured it was just a bad reaction to the WB and diagnosed me bipolar NOS, but it wasn't too long before we both figured out I really was bipolar for sure. Now that I've been diagnosed BP 1, I don't imagine it'll change, my pdoc is very conservative about labeling people and it took well over a year for him to make the final diagnosis. It doesn't really matter, the treatment is the same and he treats the person, not the label.