When I was in high school I was constantly in Drs. offices for migraines. I would get depression from time to time but this was long before my BP and mood swings appeared. During senior year and first year of college, doctor put me on Topamax which was experimental at the time for migraines. I was on it for a year and it totally messed me up - I looked and felt awful all the time. I went from overachieving and passionate to being complete disinterested in everything and everyone. The doctor would increase the dosage each time I saw him thinking it would work but my migraines never went away. I swear during that time, Topamax did something to me...like it triggered the onset of my BP. I was never the same after that. Who knows if it really triggered the onset of my BP but I am convinced it did something to my brain permanently.