I haven't had a reaction to Wellbutrin and I'm on the maximum dose of 450mg alongside a stimulant Provigil. If I were truly bipolar you would think this would trigger mania, but it is just barely lifting my depression.

In some ways I agree the diagnosis doesn't matter and is a label. But the thing is because of the fear of mania, the treatment is different in terms of meds and possible hospitalization.

I had to become extremely depressed to the point of almost giving up before my shrink allowed me a chance to take such a strongly activating combination of meds. And it is working for my depression and not causing any signs of mania. That one short reaction was the only time my whole life that I have had those symptoms or anything close to them and I'm over 50.