I know Provigil is not an anti-depressant. I am started it for fatigue associated with depression. The fatigue was so serious that I was becoming despairing because I was unsure that I would be able to work a full day in an upcoming position. It was a last ditch effort to bring me up out of that. There are studies that have shown effectiveness for depression but it is not indicated for that. I did take it before for 6 years as really the main drug for depression and did okay on it. I think I may have taken Lamictal too. I am hoping the Wellbutrin kicks in soon so I can see. I've tried so many other anti-depressants and not really had much luck. Lexapro somewhat. I am somewhat nervous about taking these two together and the Wellbutrin at the maximum dose. I wouldn't want to do that very long, but if it pulls me out for now, maybe it is worth it.