I was on Pristiq for a long time and felt it wasn't doing the job .. I talked to my doctor who promptly put me on a " medication vacation " for 35 days !
It wasn't too bad at first since he did greatly reduce the strength of the pristiq and other meds I was on .. but by the 4th week I was in trouble .. couldn't sleep .. very agitated, nervous and very depressed.
He then put me on Effexor 75mg to start then 150 mgs after that and Seroquel ( low dose) .. What a difference in my life!
So far, so good .. sure wish there was a bloody cure to this dam bi-polar crap.
It literally sucks the life out of me.