So I'm on Seroquel again unfortunately. I've been back on it for about 6 weeks and gained 6 pounds. I came off of it in March because it caused pre-diabetes and my triglycerides to go thru the roof. I then lost 30 pounds but I am back on it for sleep but also because it stabilized me. Well I saw my pdoc today and expressed my concern about the weight. He said I shouldn't be gaining any weight because I am on Metformin for my pre-diabetes. I told him I eat healthy, low calories, just water, no desserts, and I eat out once a week. I told him I lost 30 pounds as soon as I came off of the Seroquel. So he decided to put me on 25mg of Topamax in conjunction with the Seroquel and see how it goes. Does anyone have any experiences? I'm hoping this works. I've lost a total of 60 pounds and don't want to put it back on. You know it's bad enough suffering from mental illness but then to have to deal with the side effects of the medication. Sorry, just frustrated.