I have gained weight on both Metformin and Topamax. In the case of Metformin, I gained weight despite of Metformin. In the case of Topamax, I believe, and my person trainer had the same experience, that I gained weight because of it, since my body started believing that it was starving, and when you are in a starvation mode, every calorie goes right to your visceral fat.

The dr who says that you should not be gaining any weight due to Metformin is a bad dr so it is best to look for somebody else.

Seroquel ideally should not be used for sleep - there are far gentler choices for that. The best way is to avoid both Seroquel and Topamax altogether. What else have you tried for sleep? The use of Seroquel as the first treatment to try for sleep is highly objectionable, but, unfortunately, widespread.

Among gentler choices for sleep are Trazodone and Elavil. I would start with Trazodone. It can stop working with time, but, supposedly (I have not tried myself), if you give it a long break and resume taking it, it will work again.

Between Trazodone and Seroquel Trazodone very easily wins in terms of its having a far more benign side effects profile.

Of course you'd be frustrated!

Is this a pdoc or a GP?