I have had trouble with this one as well. I have been thru 4 or 5 anti-depressants in one year. Right now I am on Wellbutrin and it seems to work better than the others but it's not perfect. I am also on Topamax for migraines but it doesn't completely help the migraines and it has some ugly side effects. I had to come off buspirone because it had scary side effects.