Right now you can give him his space. There are times when our moods require alone time. Fighting bipolar is a wearing task, that honestly, can never be defeated. He said you were still best friends so maybe he just wants to have time to go through what he needs without someone telling him he will be alright. In my mind, I know no matter how stable I am I'm never going to be alright. When I am "normal" I live in fear of the next episode, forever watching, forever anticipating. As far as the meds, I think it is normal for a lot of ppl not wanting to take them. The side effects are not the greatest. Just let him know you are there if and when he needs you. Thank you for sticking by him.