I used to respond to Lexapro, but recently didn't so now I take Wellbutrin, which is helping. I had the vegetative type of depression, with extreme fatigue, so we got approval to use Provigil. That has made an enormous difference. I now feel capable and ready to do things, have the lasting power and concentration, and feel calm and focused without anxiety or sleep problems. I wish they would approve it for depression, at least these types of symptoms of depression.