You could just remind them or educate them that it's a psychiatric disorder and not a lifestyle choice, that you're not in control of "why" it exists.
Or answering a question with a question can be fun. Why is the sky blue? Why are you wearing sunglasses indoors? (Or maybe something less snarky..  )
I usually stupidly start listing off recent tragedies, and then they don't know what to say about my sad life and it's awkward. I like your idea of a short answer. 
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“We use our minds not to discover facts but to hide them. One of things the screen hides most effectively is the body, our own body, by which I mean, the ins and outs of it, its interiors. Like a veil thrown over the skin to secure its modesty, the screen partially removes from the mind the inner states of the body, those that constitute the flow of life as it wanders in the journey of each day.”
— Antonio R. Damasio, “The Feeling of What Happens: Body and Emotion in the Making of Consciousness” (p.28)
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