Thank you all! Yes, the side effects bite. Break thru episodes, more highs than lows I hope? Pdoc = psychiatrist? What is php? Sounds like a T is the thing I need to do next. I just told my spouse I needed to ask about that next pdoc appointment. I likely have anxiety PTSD OCD happening too. In some ways I am glad to have Dx as it sure does explain a lot for me and about me. I like fight or flight, prefer flight. Part of what is hard right now is I have not been released to drive post shoulder surgery which makes me very fidgety at home and work. Less so with the Seroquel but still when it is close to next dose I get twitchy. Guess this is part of finding my cocktail?