I don't know whether I'm treatment resistant, I've only had a partial response to meds this time around, despite having tried 7 different antidepressants in three years (2 poop outs, 1 allergy and 2 with unmanageable side effects). I've responded well to meds in the past, so I'm really discouraged that this time nothing seems to work. It certainly adds to the hopelessness that's for sure.