Yes, actually prozac and wellbutrin are said to work quite well together. Many people need only a small dose of prozac to add in the serotonin effects that are "missing" in the WB, which only hits the norepinephrine and dopamine. I have known someone who has Panic Disorder who has been greatly helped by this combination of 150 WB and about 15mg. prozac. (This person also takes a very small dose of a benzodiazepine).