Wow, that's interesting. Not surprising to me though, because I've only ever felt the "anti-depressant" effects of a given SSRI or SNRI within hours of first trying, and then only for the first couple of days I've been on it. I've suspected that it's because I've had migraines since I was 5 years old, that I perhaps have an enhanced ability to notice what's happening up there, since I've had a lot to "notice" for a very long time, and even during my developmental years. For me it's the desired long-term effects that I don't end up benefitting from. But I can definitely feel the product working my noodle about in various ways from outset to the eventual discontinuations.

But when I've described my initial reaction, and lack of reaction thereafter to practitioners, they've always doubted me on it, and even after taking them for as long as 8 months without long-term results, insisted I keep waiting. I've never personally experienced long-term relief from an anti-D, so I suppose mine is one of those brains described in the article as "bucking the trend". Those who know me would likely say that seems about par for the course... =P