I too have found Hydrocodone to be the best anti depressant out there. I don't have any chronic pain but on occasions (kidney stones, tooth aches, etc) I have taken it and it has totally lifted the depression while the effects lasted. I have also taken it at times when I shouldn't have to relieve depression. I am a recovering addict/ addictive personality so not a good option for me. I don't ever take it now unless I really need it for pain for some reason. Oh how I wish it wasn't addictive and had no withdrawal. They should study it more. Works better than amphetamines and I have experience with those back in my days of drug use.