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OTHER CAUSES

Other etiologies of vitamin B12 deficiency, although less common, deserve mention. Patients with evidence of vitamin B12 deficiency and chronic gastrointestinal symptoms such as dyspepsia, recurrent peptic ulcer disease, or diarrhea may warrant evaluation for such entities as Whipple's disease (a rare bacterial infection that impairs absorption), Zollinger-Ellison syndrome (gastrinoma causing peptic ulcer and diarrhea), or Crohn's disease. Patients with a history of intestinal surgery, strictures, or blind loops may have bacterial overgrowth that can compete for dietary vitamin B12 in the small bowel, as can infestation with tapeworms or other intestinal parasites. Congenital transport-protein deficiencies, including transcobalamin II deficiency, are another rare cause of vitamin B12 deficiency.

I have gastrointestinal problems...i was never diagnosed...however my doctor always assumed it was IBS because my mother has it

Clinical Manifestations

Vitamin B12 deficiency is associated with hematologic, neurologic, and psychiatric manifestations (Table 1). It is a common cause of macrocytic (megaloblastic) anemia and, in advanced cases, pancytopenia. Neurologic sequelae from vitamin B12 deficiency include paresthesias, peripheral neuropathy, and demyelination of the corticospinal tract and dorsal columns (subacute combined systems disease). Vitamin B12 deficiency also has been linked to psychiatric disorders, including impaired memory, irritability, depression, dementia and, rarely, psychosis.5,6

must i say anymore about the psychiatric manifestations??

and as for the anema...my grandmother has anema...and anema runs in our family...along with the gastrointestinal problems and even psychiatric problems....

thanks heyjoe....well i know what it may be...lol i just need money....and insurance now