seroquel made me jittery once i increased it, so had to go off. the cycling/mixed states are the worst. im also in the same spot of "i thought this was better and now it's ripped away by this illness", it sucks, and makes it feel like it's all not worth it. but i guess we have to hope for the good at the end of the rainbow when we find the right meds. But heres to trying in the meantime! Hugs!