Meds can def contribute to both feeling nothing and feelung overwhelmed. Many many yrs ago, they gave me effexor and wellbutrin together for my depression, some anxiety. In under3days, felt like crazy person-clock watching, fidgeting, feeling world going to end, overwhelmed.***just saying-check in with ur md. Alao, now whn feel overwhelmed, is usually becuz I'm worried aboutEVERYTHING.one thing that helps me, write list of what is overwhelming you, then list what I can/cannot do to help each thing. Then try to do those things.hang in there