I have taken hydrocodone for pain and it would also ease my depression, but I think that was the opiate effect. Of course when the med wears off the depression is back. Before I was put on so much medication I would have a drink to "calm my nerves". Another bad thing to do as alcohol can become addictive. I have been taking Wellbutrin since July. Recently my neurologist put me on amitriptyline to control my migraines. This medicine makes me sleepy but it does seem to help the migraines and also seems to be easing the depression. I hope the relief continues.