Zoloft is the only SSRI that works for me. I often go on it for a while then off. Zoloft is very strong! I usually feel better after 4 days of taking it BUT the side effects usually last at least 2 weeks for me, and during that period, it can be a little uncomfortable but then when the side effects do go away, you feel great! I start at 25mgs for 2 weeks then raise to 50mgs for at least 2-3 weeks then go to 100mg where I usually stay at. If I were to start at 50mg I feel too horrible for the first week!!! So I start at 25mg which is manageable for me.

It is very effective for anxiety! And really reduces depression. I have treatment resistant atypical type depression. Even though I am bipolar, zoloft seems to straiten me out better then antispychotics! Unless of course I'm psychotic which is getting more rare for me. Occasionally i do get hypomanic on zoloft but I'll take the rick because it really is the most effective for me. Give it a chance! 2 weeks at least!