That's a really hard situation. I don't know how you resolve something like that.

Would you be willing to compromise with her? Agree to take meds for six months and then re-evaluate? If they didn't work, she would see that with her own eyes. If you are already miserable and don't want to lose her, maybe it's not a bad thing to try. It wouldn't be forever, just a few months, right? I'm not saying that this is the path you should take, just throwing it out there as an idea.