I'm bipolar and love wellbutrin, the only bad thing about it for me is it does nothing for anxiety and in fact can increase it. I take the 150mg instant release, suppose to take it twice a day but dropped down to only once a day and I can even stop it for weeks at a time now. The only side effect I remember first starting it was constipation and even more trouble falling asleep. But both went away after awhile. Actually, it does nothing for my depression either, I think what I like about it most is it reduces my fatigue from other meds.